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A worldwide alert has been issued by Interpol for a bootleg drug being offered as ‘fat burners'. These tails are topic to several put up-translational covalent modifications, lawyer in my area including acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ). The exception to the rule is the DOT1 household, members of which methylate K79 within the globular area of histone H3 and that are structurally not related to SET-area proteins four - 6 Recent work suggests that SET-domain-containing proteins methylate a couple of proteins along with histones (see later)