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These tails are subject to a number of post-translational covalent modifications, including acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ).
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The hardened dental calculus on prehistoric teeth suggests that folks ate purple nutsedge, a weedy plant wealthy in carbohydrates.
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At the base of the channel is the methyltransfer pore, which connects the pocket to the AdoMet-binding cleft. Methylation been discovered on a range of lysine residues in numerous histones: K4 (using the single-letter amino-acid code for lysine), K9, K27, K36 and K79 in histone H3, K20 in histone H4, K59 within the globular area of histone H4 2 and K26 of histone H1B three A number of proteins chargeable for the methylation of specific residues have been characterized, and all however considered one of these comprises a SET area